5-Amino-1,2-dimethyl-1,2,3,4-tetrahydroisoquinoline → (+/-) N-(1,2-Dimethyl-1,2,3,4-tetrahydroisoquinolin-5-yl)-5-chloro-4-ethoxy-2-methoxybenzamide, hydrochloride
Reaktionsgleichung
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:13])[CH:7]2[CH3:12].[Cl:14][C:15]1[C:16]([O:26][CH2:27][CH3:28])=[CH:17][C:18]([O:24][CH3:25])=[C:19]([CH:23]=1)[C:20](O)=[O:21]>>[ClH:14].[CH3:12][CH:7]1[C:8]2[C:3](=[C:2]([NH:1][C:20](=[O:21])[C:19]3[CH:23]=[C:15]([Cl:14])[C:16]([O:26][CH2:27][CH3:28])=[CH:17][C:18]=3[O:24][CH3:25])[CH:11]=[CH:10][CH:9]=2)[CH2:4][CH2:5][N:6]1[CH3:13]Komponenten
3
Versuchsvorschrift
The title compound was prepared in a similar fashion to Example 1 from 5-amino-1,2-dimethyl-1,2,3,4-tetrahydroisoquinoline and 5-chloro-4-ethoxy-2-methoxybenzoic acid. The crude product was recrystallised from methanol and ethyl acetate to afford a pale brown solid (319 mg).
Aufarbeitung
- customThe crude product was recrystallised from methanol and ethyl acetate