N2 acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine → Ganciclovir

HRID 65103

Reaktionsgleichung

Reaktionsgleichung von HRID 65103
N#N.C([NH:6][C:7]1[NH:8][C:9](=[O:23])[C:10]2[N:11]=[CH:12][N:13]([CH2:16][O:17][CH:18]([CH2:21][OH:22])[CH2:19][OH:20])[C:14]=2[N:15]=1)(=O)C>N>[OH:20][CH2:19][CH:18]([O:17][CH2:16][N:13]1[CH:12]=[N:11][C:10]2[C:9](=[O:23])[NH:8][C:7]([NH2:6])=[N:15][C:14]1=2)[CH2:21][OH:22]

Komponenten

3

Edukt 1

HCID 136408871N2 acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine

Produkt 1

HCID 135398740GanciclovirAusbeute 95,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 222AmmoniaLösungsmittel

Versuchsvorschrift

N2 -Acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine (721.9 mg, 2.4 mmol) was stirred with 50 ml of methanolic ammonia solution (methanol saturated with ammonia at 0° C.) for 17 hours at 21° C. The solution was concentrated to a white solid and the residue recrystallized from water or methanol to give 582.3 mg of 9-(1,3-dihydroxy-2propoxymethyl)guanine, mp 250° C.

Aufarbeitung

  1. concentrationThe solution was concentrated to a white solid
  2. customthe residue recrystallized from water or methanol

Quellen und Nachweise

ORD-Eintrag
ord-10633569d8fa43ce88eb2ef0597f7711
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04612314

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