Methanol → Methyl 3-bromo-2,4,5-trifluorobenzoate

HRID 651284Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 651284
[Br:1][C:2]1[C:3]([F:13])=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5](F)=[O:6].[CH3:14][OH:15]>C(N(CC)CC)C>[Br:1][C:2]1[C:3]([F:13])=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5]([O:15][CH3:14])=[O:6]

Komponenten

4

Edukt 2

HCID 887MethanolHCID 141498723-Bromo-2,4,5-trifluorobenzoyl fluoride

Produkt 1

HCID 18459836Methyl 3-bromo-2,4,5-trifluorobenzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

772 g of 3-bromo-2,4,5-trifluoro-benzoyl fluoride are added dropwise to 1460 ml of methanol and 340 g of triethylamin, while cooling with ice. The mixture is stirred at room temperature for 1 hour. The reaction mixture is concentrated in vacuo and the resulting residue is taken up in water and methylene chloride. The water is extracted with methylene chloride once more. The organic phase is dried with Na2CO3 and concentrated in vacuo. The resulting residue is distilled in vacuo.

Aufarbeitung

  1. temperaturewhile cooling with ice
  2. concentrationThe reaction mixture is concentrated in vacuo
  3. extractionThe water is extracted with methylene chloride once more
  4. dry with materialThe organic phase is dried with Na2CO3
  5. concentrationconcentrated in vacuo
  6. distillationThe resulting residue is distilled in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-699b0f2431f146d18cc2d05fb5bc33fb
Quelldatensatz
uspto-grants-2001_08
Patentnummer
US06278013B1

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