Ethyl alpha-oxobenzenebutanoate → Ethyl 2-hydroxy-4-phenylbutyrate, (+-)-

Beteiligte Stoffe

Reaktionsschritte

The general procedure described in Example B1 is repeated, with the following modifications to the reaction conditions: ethyl-4-phenyl-2-oxobutyrate (substrate): 0.352 g (1.7 mmol); solvent: 10 ml of toluene/methanol (1:1); hydrogen: 50 bar, temperature: 50° C.; reaction time: 19 hours. The conversion is 100%, ee: 44% (R).

Herkunft & Nachweise