Nor-HN2 → HCID 21708342, Verbindung

HRID 651383Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 651383
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][C:4]=1[C:10]([F:13])([F:12])[F:11].[Cl-].Cl[CH2:16][CH2:17][NH2+:18][CH2:19][CH2:20]Cl>C(O)CCC>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[CH:5][C:4]=1[C:10]([F:11])([F:12])[F:13]

Komponenten

4

Edukt 2

HCID 13186Nor-HN2HCID 6007055-Amino-2-methoxybenzotrifluoride

Produkt 1

HCID 21708342HCID 21708342, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Versuchsvorschrift

A mixture of 4-methoxy-3-trifluoromethylphenylamine (12 g; 0.0627 mol) and bis(2-chloroethyl) ammonium chloride (11.2 g; 0.0627 mol) in n-butanol (120 ml) was refluxed for 10 hours. The reaction mixture was cooled at room temperature and the crude title compound precipitated as hydrochloride salt overnight. The solid was collected and crystallized from acetone. 7 g; m.p. 244-245° C.

Aufarbeitung

  1. temperaturewas refluxed for 10 hours
  2. customthe crude title compound precipitated as hydrochloride salt overnight
  3. customThe solid was collected
  4. customcrystallized from acetone

Quellen und Nachweise

ORD-Eintrag
ord-77065d2ad7124cfb88d36133bbc78dd1
Quelldatensatz
uspto-grants-2001_08
Patentnummer
US06281218B1

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