Ammonia → 2,2-Dimethyl-1,3-dioxan-5-amine

HRID 651410Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 651410
[CH3:1][C:2]1([CH3:9])[O:7][CH2:6][C:5](=O)[CH2:4][O:3]1.[NH3:10]>[Ni]>[CH3:1][C:2]1([CH3:9])[O:7][CH2:6][CH:5]([NH2:10])[CH2:4][O:3]1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 27331412,2-Dimethyl-1,3-dioxan-5-one

Produkt 1

HCID 117686082,2-Dimethyl-1,3-dioxan-5-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 935NickelKatalysator

Versuchsvorschrift

6.1 g (47 mmol) of 2,2-dimethyl-1,3-dioxan-5-one (D. Enders, B. Bockstiegel, Synthesis 1989, 493, incorporated herein by reference) were subjected to reductive amination in 50 ml of ammonia—saturated methanol in an autoclave at 50° C. under a hydrogen pressure of 100 bar, using Raney nickel as the catalyst. After the catalyst had been filtered off and the filtrate concentrated, 4.8 g of a brown oil were obtained, this being further reacted without purification.

Aufarbeitung

  1. customBockstiegel, Synthesis 1989, 493
  2. filtrationAfter the catalyst had been filtered off
  3. concentrationthe filtrate concentrated

Quellen und Nachweise

ORD-Eintrag
ord-f2c76cee99944860a5030a738a043846
Quelldatensatz
uspto-grants-2001_08
Patentnummer
US06281221B1

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