Diethylene Glycol → 2-(2-((Tert-butyldimethylsilyl)oxy)ethoxy)ethanol

HRID 651504

Reaktionsgleichung

Reaktionsgleichung von HRID 651504
[CH2:1]([OH:7])[CH2:2][O:3][CH2:4][CH2:5][OH:6].[H-].[Na+].[Cl-].[CH3:11][SiH:12]([CH3:17])[C:13]([CH3:16])([CH3:15])[CH3:14]>O1CCCC1>[CH3:14][C:13]([Si:12]([CH3:17])([CH3:11])[O:7][CH2:1][CH2:2][O:3][CH2:4][CH2:5][OH:6])([CH3:16])[CH3:15]

Komponenten

5

Edukt 3

HCID 8117Diethylene GlycolHCID 24758Sodium hydrideHCID 131722836Tert-butyldimethylsilane chloride

Produkt 1

HCID 111175822-(2-((Tert-butyldimethylsilyl)oxy)ethoxy)ethanolAusbeute 97,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

20 g of diethyleneglycol is added to 9.05 g of sodium hydride in 320 cm3 of tetrahydrofuran, the reaction medium is agitated for 45 minutes, 28.3 g of dimethylterbutylsilane chloride is added, agitation is carried out for 3 hours while leaving the temperature to return to ambient. Extraction is carried out with ether, followed by washing with an aqueous solution of sodium bicarbonate, with salt water, drying and evaporating the solvent. 40.25 g of expected product is obtained.

Aufarbeitung

  1. waitagitation is carried out for 3 hours
  2. customwhile leaving the temperature
  3. extractionExtraction
  4. washby washing with an aqueous solution of sodium bicarbonate, with salt water
  5. customdrying
  6. customevaporating the solvent

Quellen und Nachweise

ORD-Eintrag
ord-ea06e4a76b824325b25c383d0b6d803b
Quelldatensatz
uspto-grants-2001_08
Patentnummer
US06281204B1

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