5'-Chloro-2,2'-bithiophene-5-sulfonyl chloride → HCID 69709209, Verbindung

HRID 651673

Reaktionsgleichung

Reaktionsgleichung von HRID 651673
[Cl:1][C:2]1[S:6][C:5]([C:7]2[S:8][C:9]([S:12](Cl)(=[O:14])=[O:13])=[CH:10][CH:11]=2)=[CH:4][CH:3]=1.[C:16]([O:20][C:21]([N:23]1[C:31]2[CH:30]=[CH:29][N:28]=[CH:27][C:26]=2[CH:25]=[C:24]1[CH2:32][N:33]1[CH2:37][CH2:36][C@H:35]([NH2:38])[C:34]1=[O:39])=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([N:23]1[C:31]2[CH:30]=[CH:29][N:28]=[CH:27][C:26]=2[CH:25]=[C:24]1[CH2:32][N:33]1[CH2:37][CH2:36][C@H:35]([NH:38][S:12]([C:9]2[S:8][C:7]([C:5]3[S:6][C:2]([Cl:1])=[CH:3][CH:4]=3)=[CH:11][CH:10]=2)(=[O:14])=[O:13])[C:34]1=[O:39])=[O:22])([CH3:19])([CH3:17])[CH3:18]

Komponenten

3

Edukt 2

HCID 220172805'-Chloro-2,2'-bithiophene-5-sulfonyl chlorideHCID 54368269HCID 54368269, Verbindung

Produkt 1

HCID 69709209HCID 69709209, Verbindung

Versuchsvorschrift

The title compound is prepared as described in EXAMPLE 56, Part A using 5′-chloro-[2,2′]bithiophenyl-5-sulfonyl chloride and 2-[3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester as starting material. The crude product can be purified by column chromatography eluting with 5% MeOH/CH2Cl2 to give the title compound as a white solid or used in the subsequent step after an aqueous work-up without further purification.

Aufarbeitung

  1. customThe title compound is prepared
  2. customThe crude product can be purified by column chromatography
  3. washeluting with 5% MeOH/CH2Cl2

Quellen und Nachweise

ORD-Eintrag
ord-45cbc60524734fecb891f6b069bdafe8
Quelldatensatz
uspto-grants-2001_08
Patentnummer
US06281227B1

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