HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → 3-[6-(1H-Imidazol-2-yl)-1-methyl-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Ethanol | HCID 702 | — |
| Edukt | 1-methyl-6-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-1H-indole | HCID 21709055 | — |
| Edukt | Isopropyl 1-methyl-3-indoleacetimidate hydrochloride | HCID 22907276 | — |
| Produkt | 3-[6-(1H-Imidazol-2-yl)-1-methyl-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione | HCID 10202360 | 14% |
Reaktionsschritte
3-[6-(1H-Imidazol-2-yl)-1-methyl-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione (37 mg, 14%) was prepared as an orange solid using 1-methyl-6-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-1H-indole (200 mg, 0.61 mmol) and 1-methyl-3-indoleacetimidic acid isopropyl ester hydrochloride (162 mg, 0.61 mmol) followed by deprotection using 20% HCl in refluxing EtOH.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06281356B1 |
| Quelldatensatz | uspto-grants-2001_08 |
| ORD ID | ord-1cf4dfeba95747aabc7cf86752aff57a |
| Quellennotiz | uspto-grants-2001_08 |