Sodium Hydroxide → N-[4-[14-(Trimethylsilyl)tetradecylamino]benzoyl)glycine

HRID 652032

Reaktionsgleichung

Reaktionsgleichung von HRID 652032
[CH3:1][Si:2]([CH3:34])([CH3:33])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[CH:32]=[CH:31][C:21]([C:22](=[O:30])[NH:23][CH2:24][C:25]([O:27]CC)=[O:26])=[CH:20][CH:19]=1.[OH-].[Na+]>C(O)C>[CH3:34][Si:2]([CH3:1])([CH3:33])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[CH:19]=[CH:20][C:21]([C:22]([NH:23][CH2:24][C:25]([OH:27])=[O:26])=[O:30])=[CH:31][CH:32]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 20198242Ethyl 4-[14-(trimethylsilyl)tetradecylamino]hippurate

Produkt 1

HCID 20198286N-[4-[14-(Trimethylsilyl)tetradecylamino]benzoyl)glycine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 12.5 g. of ethyl 4-[14-(trimethylsilyl)tetradecylamino]hippurate, 55 ml. of 1N sodium hydroxide solutions and 50 ml. of ethanol is stirred at ambient temperature for 2 hours and then partially evaporated. The aqueous solution is washed with diethyl ether, acidified with 6N hydrochloric acid, and filtered. The solid is dried in vacuo and recrystallized to yield the product as a white solid.

Aufarbeitung

  1. additionA mixture of 12.5 g
  2. custompartially evaporated
  3. washThe aqueous solution is washed with diethyl ether
  4. filtrationfiltered
  5. customThe solid is dried in vacuo
  6. customrecrystallized

Quellen und Nachweise

ORD-Eintrag
ord-51d702da3ab148408fdf35a26672fdea
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04670421

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