4-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}aniline → 1,3-Dimethyl-5-[4-(5-trifluoromethylpyrid-2-yloxy)phenylcarbamoyl]-2-thiobarbituric acid

HRID 652061Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 652061
[CH3:1][N:2]1[C:9](=[O:10])[CH:8]([C:11]([O:13]CC)=O)[C:6](=[O:7])[N:5]([CH3:16])[C:3]1=[S:4].[F:17][C:18]([F:34])([F:33])[C:19]1[CH:20]=[CH:21][C:22]([O:25][C:26]2[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=2)=[N:23][CH:24]=1>CN(C)C=O>[CH3:16][N:5]1[C:6](=[O:7])[CH:8]([C:11](=[O:13])[NH:30][C:29]2[CH:31]=[CH:32][C:26]([O:25][C:22]3[CH:21]=[CH:20][C:19]([C:18]([F:34])([F:17])[F:33])=[CH:24][N:23]=3)=[CH:27][CH:28]=2)[C:9](=[O:10])[N:2]([CH3:1])[C:3]1=[S:4]

Komponenten

4

Edukt 2

HCID 27830854-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}anilineHCID 140533471,3-Dimethyl-5-ethoxycarbonyl-2-thiobarbituric acid

Produkt 1

HCID 140533611,3-Dimethyl-5-[4-(5-trifluoromethylpyrid-2-yloxy)phenylcarbamoyl]-2-thiobarbituric acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

2.5 g (10 mmol) of 1,3-dimethyl-5-ethoxycarbonyl-2-thiobarbituric acid, 2,55 g (10 mmol) of 4-(5-trifluoromethylpyrid-2-yloxy)aniline and 5 ml of dimethylformamide are stirred for 6 hours at 118° C. The reaction mixture is then cooled, triturated with water and the crystalline precipitate is isolated by filtration. The crude product is recrystallised from ethanol. Melting point 156°-158° C.

Aufarbeitung

  1. temperatureThe reaction mixture is then cooled
  2. customtriturated with water
  3. customthe crystalline precipitate is isolated by filtration
  4. customThe crude product is recrystallised from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-1ece00a06c314f4e802ebf7efa6ecb2e
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04670441

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