Ammonia → 5-[4-[3-(1-Piperidinylmethyl)phenoxy]butyl]amino-1H-1,2,4-triazole-3-carboxamide

HRID 652095Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 652095
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:27]=[CH:28][CH:29]=2)[O:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17]2[NH:21][N:20]=[C:19]([C:22](OCC)=[O:23])[N:18]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH3:30]>>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:27]=[CH:28][CH:29]=2)[O:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17]2[NH:21][N:20]=[C:19]([C:22]([NH2:30])=[O:23])[N:18]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 178470502HCID 178470502, Verbindung

Produkt 1

HCID 1785138585-[4-[3-(1-Piperidinylmethyl)phenoxy]butyl]amino-1H-1,2,4-triazole-3-carboxamide

Versuchsvorschrift

A suspension of ethyl 5-[4-[3-(1-piperidinylmethyl)phenoxy]butyl]amino-1H-1,2,4-triazole-3-carboxylate (867 mg) in 0.88 ammonia (25 ml) was stirred at room temperature for 18 h. The mixture was evaporated and the residual solid was washed with boiling methanol to leave the title compound as a white solid (255 mg) m.p. 212°-4° dec.

Aufarbeitung

  1. customThe mixture was evaporated
  2. washthe residual solid was washed with boiling methanol

Quellen und Nachweise

ORD-Eintrag
ord-14c83efbb5a6445a914eda5e07f698f2
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04670448

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