HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sulfate Ion → 1-(2-Cyclohexyl-4-quinolyl)-3-(4-piperidyl)-1-propanol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sulfate Ion | HCID 1117 | — |
| Edukt | Sodium Hydroxide | HCID 14798 | — |
| Edukt | Sodium borohydride | HCID 4311764 | — |
| Edukt | Sodium Methoxide | HCID 10942334 | — |
| Edukt | 1-(2-Cyclohexyl-4-quinolyl)-3-(4-piperidyl)-1-propanone monohydrochloride | HCID 20234127 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 1-(2-Cyclohexyl-4-quinolyl)-3-(4-piperidyl)-1-propanol | HCID 20234116 | 28% |
Reaktionsschritte
The operation was as in Example 5, starting from 5.1 g of 1-(2-cyclohexyl-4-quinolyl)-3-(4-piperidyl)-1-propanone monohydrochloride, 1.3 ml of a 10N aqueous solution of sodium hydroxide (instead of sodium methylate) and 0.53 g of sodium borohydride in 100 ml of ethanol. 1.3 g of 1-(2-cyclohexyl-4-quinolyl)-3-(4-piperidyl)-1-propanol (racemic) were finally obtained in the form of the sulfate melting at 260° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04613607 |
| Quelldatensatz | uspto-grants-1986_09 |
| ORD ID | ord-e12560ad974f41aba543abacd5ee998d |
| Quellennotiz | uspto-grants-1986_09 |