Sodium Hydroxide → 2-Amino-3-biphenylacetic Acid Hydrate

HRID 652265

Reaktionsgleichung

Reaktionsgleichung von HRID 652265
[C:1]1([C:7]2[CH:8]=[CH:9][CH:10]=[C:11]3[C:15]=2[NH:14][C:13](=[O:16])[CH2:12]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:17].[Na+]>>[OH2:16].[NH2:14][C:15]1[C:11]([CH2:12][C:13]([OH:16])=[O:17])=[CH:10][CH:9]=[CH:8][C:7]=1[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

3

Edukt 2

HCID 14798Sodium HydroxideHCID 133019777-phenyl-2,3-dihydro-1H-indol-2-one

Produkt 1

HCID 133019802-Amino-3-biphenylacetic Acid Hydrate

Versuchsvorschrift

A mixture of 4.5 g. (0.0215 mole) of 7-phenylindolin-2-one and 60 ml. of 3N sodium hydroxide was heated at reflux under nitrogen for 17 hrs. The reaction mixture was cooled, filtered, and the filtrate was diluted with 60 ml. of water. The solution was cooled, made acidic with glacial acetic acid and the resulting tan solid was immediately collected by filtration, washed with cold water and dried under vacuum to yield 4.6 g. (98%) of product as a tan solid, m.p. 98°-100° C. (dec.).

Aufarbeitung

  1. additionA mixture of 4.5 g
  2. temperatureat reflux under nitrogen for 17 hrs
  3. temperatureThe reaction mixture was cooled
  4. filtrationfiltered
  5. additionthe filtrate was diluted with 60 ml
  6. temperatureThe solution was cooled
  7. filtrationthe resulting tan solid was immediately collected by filtration
  8. washwashed with cold water
  9. customdried under vacuum
  10. customto yield 4.6 g

Quellen und Nachweise

ORD-Eintrag
ord-810bec54eeb64820b53974d38f8faaf2
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04670566

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