1-(4-Chlorophenyl)-2-butyn-1-ol → (Z)-1-(4-chlorophenyl)-2-buten-1-ol

HRID 65235Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 65235
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:12])[C:9]#[C:10][CH3:11])=[CH:4][CH:3]=1>[Pd].CC([O-])=O.CC([O-])=O.[Pb+2]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([OH:12])/[CH:9]=[CH:10]\[CH3:11])=[CH:6][CH:7]=1

Komponenten

3

Edukt 1

HCID 201883391-(4-Chlorophenyl)-2-butyn-1-ol

Produkt 1

HCID 67901371(Z)-1-(4-chlorophenyl)-2-buten-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 131709914Lindlars catalystKatalysator

Versuchsvorschrift

Under nitrogen, hydrogenate a mixture of 10 g (0.055 mole) of 1-(4-chlorophenyl)-2-butyn-1-ol and 0.6 g Lindlar catalyst. Following the reaction vic NMR the reaction is complete in about two days. The hydrogenation is stopped and the reaction stirred under N2 at room temperature overnight. Filter off the catalysts, wash with methylene chloride combine the filtrate and evaporate to yield the title compound.

Aufarbeitung

  1. filtrationFilter off the catalysts
  2. washwash with methylene chloride
  3. customevaporate

Quellen und Nachweise

ORD-Eintrag
ord-1ba35f007e7240af90d3407e16dabfe8
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04613609

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