4-(Pyridin-3-yloxy)butan-1-amine → 6-(4-acetyl-3-hydroxy-2-propylphenoxy)-N-[4-(3-pyridinyloxy)butyl]hexanamide
Reaktionsgleichung
[C:1]([C:4]1[CH:18]=[CH:17][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=O)=[C:6]([CH2:19][CH2:20][CH3:21])[C:5]=1[OH:22])(=[O:3])[CH3:2].[N:23]1[CH:28]=[CH:27][CH:26]=[C:25]([O:29][CH2:30][CH2:31][CH2:32][CH2:33][NH2:34])[CH:24]=1>>[C:1]([C:4]1[CH:18]=[CH:17][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([NH:34][CH2:33][CH2:32][CH2:31][CH2:30][O:29][C:25]2[CH:24]=[N:23][CH:28]=[CH:27][CH:26]=2)=[O:16])=[C:6]([CH2:19][CH2:20][CH3:21])[C:5]=1[OH:22])(=[O:3])[CH3:2]Komponenten
3
Versuchsvorschrift
6-(4-Acetyl-3-hydroxy-2-propylphenoxy)hexanoic acid was allowed to react with 4-(3-pyridinyloxy)butyl amine according to procedure A and the product was purified by HPLC to give 6-(4-acetyl-3-hydroxy-2-propylphenoxy)-N-[4-(3-pyridinyloxy)butyl]hexanamide, the title compound, mp 50°-53° (from ethyl acetate) in 73% yield.
Aufarbeitung
- customthe product was purified by HPLC