Thionyl Chloride → 2-Methoxy-3-isopropyl-5-sulphamoyl-6-methylbenzoyl chloride

HRID 652757Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 652757
[CH3:1][O:2][C:3]1[C:11]([CH:12]([CH3:14])[CH3:13])=[CH:10][C:9]([S:15](=[O:18])(=[O:17])[NH2:16])=[C:8]([CH3:19])[C:4]=1[C:5](O)=[O:6].S(Cl)([Cl:22])=O>CN(C)C=O.C(Cl)(Cl)Cl>[CH3:1][O:2][C:3]1[C:11]([CH:12]([CH3:14])[CH3:13])=[CH:10][C:9]([S:15](=[O:18])(=[O:17])[NH2:16])=[C:8]([CH3:19])[C:4]=1[C:5]([Cl:22])=[O:6]

Komponenten

5

Edukt 2

HCID 24386Thionyl Chloride2×HCID 201968382-Methoxy-3-isopropyl-5-sulphamoyl-6-methylbenzoic acid

Produkt 1

HCID 201968202-Methoxy-3-isopropyl-5-sulphamoyl-6-methylbenzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

72 g of 2-methoxy-3-isopropyl-5-sulphamoyl-6-methylbenzoic acid (0.25 mole), 250 ml of chloroform, 23 ml of thionyl chloride and 3 drops of dimethylformamide are placed in a 1 liter flask fitted with an agitator and a condenser. The mixture is heated to reflux for 1.5 hours, then 18 ml of thionyl chloride is added and the reflux is continued for 1.5 hours. The solids dissolve completely.

Aufarbeitung

  1. customfitted with an agitator and a condenser
  2. temperatureThe mixture is heated
  3. temperatureto reflux for 1.5 hours
  4. dissolutionThe solids dissolve completely

Quellen und Nachweise

ORD-Eintrag
ord-d2d56191e7bf4e59bfa653ea03ba0440
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04673686

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