Acetyl chloride → Methyl 2-Benzyloxy-2-methylpropionate

HRID 653040Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 653040
[CH2:1]([O:8][C:9]([CH3:14])([CH3:13])[C:10]([OH:12])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:15](Cl)(=O)C>CO>[CH2:1]([O:8][C:9]([CH3:14])([CH3:13])[C:10]([O:12][CH3:15])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 6367Acetyl chlorideHCID 113445632-(Benzyloxy)-2-methylpropanoic acid

Produkt 1

HCID 13716841Methyl 2-Benzyloxy-2-methylpropionate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

2-Benzyloxy-2-methylpropionic acid (4.4 g., 0.0023 mol) was dissolved in 50 ml. of methanol treated with acetyl chloride (1.61 ml., 1.78 g., 0.0023 mol), stirred for 16 hours, stripped to an oil, taken up in 75 ml. ethyl acetate, washed 1×50 ml. saturated NaHCO3 and 1×50 ml. brine, dried over MgSO4 and stripped to yield purified title product as a second oil, 4.22 g.; 1H-nmr 1.5 (s, 6H), 3.8 (s, 3H), 4.5 (s, 2H), 7.3-7.5 (m, 5H).

Aufarbeitung

  1. washethyl acetate, washed 1×50 ml
  2. dry with materialbrine, dried over MgSO4
  3. customto yield
  4. custompurified title product as a second oil, 4.22 g

Quellen und Nachweise

ORD-Eintrag
ord-32692ca7e0bc4a0d85e54c68f8d628d3
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04675186

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