2-Bromopropane → HCID 13840807, Verbindung

HRID 653147Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 653147
[CH3:1][C:2](C)([O-])[CH3:3].[K+].[CH3:7][O:8][C:9]([C:11]1[N:12]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:13]2[C:18]([C:19]=1[OH:20])=[CH:17][C:16]([O:21][CH3:22])=[CH:15][CH:14]=2)=[O:10].BrC(C)C>CS(C)=O>[CH3:7][O:8][C:9]([C:11]1[N:12]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:13]2[C:18]([C:19]=1[O:20][CH:2]([CH3:3])[CH3:1])=[CH:17][C:16]([O:21][CH3:22])=[CH:15][CH:14]=2)=[O:10]

Komponenten

5

Edukt 3

HCID 63582-BromopropaneHCID 23665647Potassium tert-butoxideHCID 54696100Methyl 3-hydroxy-5-methoxy-1-phenyl-1H-indole-2-carboxylate

Produkt 1

HCID 13840807HCID 13840807, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel2×

Versuchsvorschrift

A stirred mixture of 24.8 g (0.22 mole) of potassium tert-butoxide in 100 ml of dimethyl sulfoxide (under a nitrogen atmosphere) was placed in a cold water bath. A solution of 44.6 g (0.15 mole) of 3-hydroxy-5-methoxy-1-phenyl-1H-indole-2-carboxylic acid methyl ester [P. C. Unangst and M. E. Carethers, J. Heterocyclic Chem., 21, 709 (1984)] in 100 ml of dimethyl sulfoxide was added over 30 minutes. The new mixture was stirred for an additional 45 minutes, and 25.0 ml (32.8 g, 0.27 mole) of 2-bromopropane was added in one portion. The cooling bath was removed, and the mixture was stirred at room temperature for 45 hours, then added to 2.5 kg ice water. The crude ester intermediate was removed by extracting with dichloromethane (4×800 ml). The combined organic layers were washed with water (1×2.0 l), 5% aqueous sodium bicarbonate (2×2.0 l), and water again (1×2.0 l), before being dried with anhydrous sodium sulfate. Evaporation (vacuum) yielded a crude residue of 5-methoxy-3-(1-methylethoxy)-1-phenyl-1H-indole-2-carboxylic acid methyl ester.

Aufarbeitung

  1. customwas placed in a cold water bath
  2. customThe cooling bath was removed
  3. stirringthe mixture was stirred at room temperature for 45 hours
  4. additionadded to 2.5 kg ice water
  5. customThe crude ester intermediate was removed
  6. extractionby extracting with dichloromethane (4×800 ml)
  7. washThe combined organic layers were washed with water (1×2.0 l), 5% aqueous sodium bicarbonate (2×2.0 l), and water again (1×2.0 l)
  8. dry with materialbefore being dried with anhydrous sodium sulfate
  9. customEvaporation (vacuum)

Quellen und Nachweise

ORD-Eintrag
ord-98dad10e52424038936cb44a247d37c5
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04675332

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