2-(4-Chlorophenylmethylamino)-5-fluoronitrobenzene → 2-(4-Chlorobenzylamino)-5-fluoroaniline

HRID 653665Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 653665
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=2[N+:17]([O-])=O)=[CH:4][CH:3]=1>O1CCCC1.[Ni]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=2[NH2:17])=[CH:4][CH:3]=1

Komponenten

4

Edukt 1

HCID 149529762-(4-Chlorophenylmethylamino)-5-fluoronitrobenzene

Produkt 1

HCID 149529912-(4-Chlorobenzylamino)-5-fluoroanilineAusbeute 91,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

41.7 g of 2-(4-chlorophenylmethylamino)-5-fluoronitrobenzene, prepared in Example 1, are dissolved in 1 l of tetrahydrofuran and hydrogenated at ordinary temperature and pressure in the presence of 5 g of Raney nickel. When the theoretical amount of hydrogen has been absorbed, the catalyst is filtered off and the solvent is evaporated off under vacuum to give 34.1 g of 2-(4-chlorophenylmethylamino)-5-fluoroaniline in the form of crystals melting at 99° C.

Aufarbeitung

  1. customWhen the theoretical amount of hydrogen has been absorbed
  2. filtrationthe catalyst is filtered off
  3. customthe solvent is evaporated off under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-9ff440c34b6b4fd8877eb13a20799d85
Quelldatensatz
uspto-grants-1992_07
Patentnummer
US05128359

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