Octopamine → 1-(4-Hydroxyphenyl)-2-[1-methyl-2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl) ethylamino]ethanol

HRID 653689

Reaktionsgleichung

Reaktionsgleichung von HRID 653689
[CH3:1][N:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]1[CH2:12][C:13](=O)[CH3:14].[NH2:16][CH2:17][CH:18]([C:20]1[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=1)[OH:19]>>[OH:26][C:23]1[CH:22]=[CH:21][C:20]([CH:18]([OH:19])[CH2:17][NH:16][CH:13]([CH3:14])[CH2:12][CH:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH2:10][CH2:11][N:2]2[CH3:1])=[CH:25][CH:24]=1

Komponenten

3

Edukt 2

HCID 4581OctopamineHCID 19889952(2-Methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetone

Produkt 1

HCID 538368421-(4-Hydroxyphenyl)-2-[1-methyl-2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl) ethylamino]ethanolAusbeute 47 %

Versuchsvorschrift

The same procedure as described in Example 1 was repeated, using (2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)acetone [Synthesis, 1001 (1988)]and 2-amino-1-(4-hydroxyphenyl)ethanol, to give crude crystals. The crude crystals were washed with ether to give crystals of Compound 31 in a yield of 47%.

Aufarbeitung

  1. customto give crude crystals
  2. washThe crude crystals were washed with ether

Quellen und Nachweise

ORD-Eintrag
ord-0181e04473a147a3bd2da95f58cbe718
Quelldatensatz
uspto-grants-1992_07
Patentnummer
US05128369

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