Hydrochloric Acid → 5,6-Dihydroxy-3,4-dihydronaphthalen-1(2H)-one

HRID 653754Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 653754
C[O:2][C:3]1[C:12]([O:13]C)=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][CH2:7][C:8]2=[O:15].[Cl-].[Al+3].[Cl-].[Cl-].Cl>C1(C)C=CC=CC=1>[OH:2][C:3]1[C:12]([OH:13])=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][CH2:7][C:8]2=[O:15]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 6451240Aluminum(III) ChlorideHCID 82192465,6-dimethoxy-1-tetralone

Produkt 1

HCID 123536405,6-Dihydroxy-3,4-dihydronaphthalen-1(2H)-oneAusbeute 95,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a solution 5,6-dimethoxy-1-tetralone (100 g) in toluene (958 ml) was added aluminum chloride (200 g) in small portions. After the addition was complete the reaction was heated to 80° C. and mechanically stirred for 2 hours. The reaction was cooled and slowly poured into ice and concentrated HCl. The resulting solids were filtered and washed with cold dilute HCl. the resulting solids were taken up into monoglyme, dried (MgSO4), filtered, treated with charcoal, refiltered and concentrated. The residue was co-concentrated with acetonitrile to provide upon cooling 82.5 g of desired product as an off white solid, m.p. 191°-194° C.

Aufarbeitung

  1. additionAfter the addition
  2. temperatureThe reaction was cooled
  3. filtrationThe resulting solids were filtered
  4. washwashed with cold dilute HCl
  5. dry with materialdried (MgSO4)
  6. filtrationfiltered
  7. additiontreated with charcoal
  8. concentrationconcentrated
  9. customto provide

Quellen und Nachweise

ORD-Eintrag
ord-24bd216ce9dd479eb624f0dad1c7b60d
Quelldatensatz
uspto-grants-1992_07
Patentnummer
US05128362

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