HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Monobasic potassium phosphate → Ribavirin
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Monobasic potassium phosphate | HCID 516951 | — |
| Edukt | HCID 178513825 | HCID 178513825 | — |
| Edukt | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-hydroxypurin-9-yl)oxolane-3,4-diol | HCID 178521066 | — |
| Produkt | Ribavirin | HCID 37542 | 74,88% |
Reaktionsschritte
After completion of the cultivation, the cells were collected by centrifugation, washed and a sterilized water was added thereto to obtain 250 ml of a cell suspension. Into 750 ml of an aqueous solution containing 66.7 mM 1,2,4-triazole-3-carboxamide, 66.7 mM inosine and 100 mM monopotassium dihydrogen phosphate was added 250 ml of the above cell suspension, and the reaction was carried out at 60° C. for 24 hours (ribavirin yield: 74.88%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04614719 |
| Quelldatensatz | uspto-grants-1986_09 |
| ORD ID | ord-5d3d90781b2745c6ba6d29a8baff8dd4 |
| Quellennotiz | uspto-grants-1986_09 |