Monobasic potassium phosphate → Ribavirin

HRID 65428

Reaktionsgleichung

Reaktionsgleichung von HRID 65428
[NH:1]1[CH:5]=[N:4][C:3]([C:6]([NH2:8])=[O:7])=[N:2]1.[O:9]=[CH:10][C@@H:11]([C@@H:13]([C@@H:15]([CH2:17][OH:18])[OH:16])[OH:14])O.P([O-])(O)(O)=O.[K+]>>[CH:5]1[N:1]([C@@H:17]2[O:18][C@H:11]([CH2:10][OH:9])[C@@H:13]([OH:14])[C@H:15]2[OH:16])[N:2]=[C:3]([C:6]([NH2:8])=[O:7])[N:4]=1

Komponenten

4

Edukt 3

HCID 516951Monobasic potassium phosphateHCID 5311110Aldehydo-D-riboseHCID 178513825HCID 178513825, Verbindung

Produkt 1

HCID 37542Ribavirin

Versuchsvorschrift

To each cell suspension was added each 1 ml of an aqueous solution (pH 7.0) containing 20 mM 1,2,4-triazole-3-carboxamide, 20 mM of each of the various ribose donors as shown in Table 3 and 25 mM of monopotassium dihydrogen phosphate, and the reaction was carried out at 60° C. for 24 hours. After completion of the reaction, the cells were removed by centrifugation, and the supernatant was analyzed to obtain the results of ribavirin yield as shown in Table 3.

Aufarbeitung

  1. customAfter completion of the reaction
  2. customthe cells were removed by centrifugation
  3. customto obtain the

Quellen und Nachweise

ORD-Eintrag
ord-9e8e654260814970a075e1d7bf3a873c
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04614719

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