Monobasic potassium phosphate → Ribavirin
Reaktionsgleichung
[NH:1]1[CH:5]=[N:4][C:3]([C:6]([NH2:8])=[O:7])=[N:2]1.P([O-])(O)(O)=O.[K+].[O:15]=[CH:16][C@@H:17]([C@@H:19]([C@@H:21]([CH2:23][OH:24])[OH:22])[OH:20])O>>[CH:5]1[N:1]([C@@H:23]2[O:24][C@H:17]([CH2:16][OH:15])[C@@H:19]([OH:20])[C@H:21]2[OH:22])[N:2]=[C:3]([C:6]([NH2:8])=[O:7])[N:4]=1Komponenten
4
Versuchsvorschrift
To each suspension was added each 1 ml of an aqueous solution (pH 7.0) containing 20 mM 1,2,4-triazole-3-carboxamide, 20 ml of various ribose donors as shown in Table 10 and 25 mM monopotassium dihydrogen phosphate, and the reaction was carried out at 60° C. for 20 hours. After the reaction, the microbial cells were removed by centrifugation and the supernatant was analyzed to give the results of ribavirin yields as shown in Table 10.