trans-N-[3-(3-pyridyl)cyclohexyl]phthalimide → trans-3-(3-Pyridyl)cyclohexylamine

HRID 655171Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 655171
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C@H:7]2[CH2:12][CH2:11][CH2:10][C@H:9]([N:13]3C(=O)C4=CC=CC=C4C3=O)[CH2:8]2)[CH:2]=1>CCO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C@H:7]2[CH2:12][CH2:11][CH2:10][C@H:9]([NH2:13])[CH2:8]2)[CH:2]=1

Komponenten

3

Edukt 1

HCID 67133459trans-N-[3-(3-pyridyl)cyclohexyl]phthalimide

Produkt 1

HCID 67133702trans-3-(3-Pyridyl)cyclohexylamineAusbeute 62,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of trans-N-[3-(3-pyridyl)cyclohexyl]phthalimide (3.00 g, 9.79 mmol) and hydrazinemonohydorate (0.95 mL, 19.6 mmol) in EtOH (40 mL) was stirred at room temperature for 1.5 h. The reaction mixture was filtered followed by the removal of solvent. The crude product was purified by column chromatography (NH, EtOAc) to yield trans-3-(3-pyridyl)cyclohexylamine (1.08 g, 60%) as colorless oil.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customfollowed by the removal of solvent
  3. customThe crude product was purified by column chromatography (NH, EtOAc)

Quellen und Nachweise

ORD-Eintrag
ord-74dd4d4486cf4557ae5649deffc813e6
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08071591B2

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