cis-N-[3-(3-pyridyl)cyclohexyl]phthalimide → cis-3-(3-Pyridyl)cyclohexylamine

HRID 655175Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 655175
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C@@H:7]2[CH2:12][CH2:11][CH2:10][C@H:9]([N:13]3C(=O)C4=CC=CC=C4C3=O)[CH2:8]2)[CH:2]=1>CCO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C@@H:7]2[CH2:12][CH2:11][CH2:10][C@H:9]([NH2:13])[CH2:8]2)[CH:2]=1

Komponenten

3

Edukt 1

HCID 67133879cis-N-[3-(3-pyridyl)cyclohexyl]phthalimide

Produkt 1

HCID 67134050cis-3-(3-Pyridyl)cyclohexylamineAusbeute 36.904,199 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of cis-N-[3-(3-pyridyl)cyclohexyl]phtalimide (1.64 g, 5.35 mmol) and hydrazinemonohydorate (0.52 mL, 10.7 mmol) in EtOH (25 mL) was stirred at room temperature for 2 h. The reaction mixture was filtered followed by the removal of solvent. The crude product was purified by column chromatography (NH, EtOAc) to yield cis-3-(3-pyridyl)cyclohexylamine (348 g, 37%) as colorless oil.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customfollowed by the removal of solvent
  3. customThe crude product was purified by column chromatography (NH, EtOAc)

Quellen und Nachweise

ORD-Eintrag
ord-3d83ef17f8a24d90af4e87a4c80cbbfe
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08071591B2

Notizen zur Reaktion

Wird geladen…