Phosphorus oxychloride → (6-Chloro-2-pyridinyl)phenylmethanone
Reaktionsgleichung
[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N+:10]=1[O-])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:18]>>[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([Cl:18])[N:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Komponenten
3
Versuchsvorschrift
1.5 g 2-benzoyl-pyridine N-oxide (T. Kato et. al., see reference in Ex. 11) and 3.6 ml POCl3 are refluxed for 25 minutes. The cooled mixture is added to slightly alkaline ice:water, extracted with chloroform, the organic extract dried and solvent removed in vacuo. Yield: 1.1 g of title product, which by thin layer and gas chromatography is identical with that described in Ex. 7.
Aufarbeitung
- additionThe cooled mixture is added to slightly alkaline ice
- extractionwater, extracted with chloroform
- extractionthe organic extract
- customdried
- customsolvent removed in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-75a734f4b7af4e6c92462028b3194e26
- Quelldatensatz
- uspto-grants-1986_09
- Patentnummer
- US04614833
Notizen zur Reaktion
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