3-Benzoyl-2-chloropyridine → 3-Pyridinemethanol, 2-chloro-alpha-phenyl-

HRID 65536

Reaktionsgleichung

Reaktionsgleichung von HRID 65536
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]([C:15]1[C:16]([Cl:21])=[N:17][CH:18]=[CH:19][CH:20]=1)(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>N1C=CC=CC=1>[Cl:21][C:16]1[C:15]([CH:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[OH:14])=[CH:20][CH:19]=[CH:18][N:17]=1

Komponenten

4

Edukt 2

HCID 8246193-Benzoyl-2-chloropyridineHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 30619803-Pyridinemethanol, 2-chloro-alpha-phenyl-Ausbeute 42,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

2.4 g lithium aluminium hydride is added very slowly to 10.6 g 3-benzoyl-2-chloropyridine in 100 ml anhydrous pyridine. After stirring for 2 hrs. at room temperature, the solvent is distilled in vacuo, the residue is added to 5% aqueous HCl and extracted with ether. Working as usual there is obtained 4.5 g of a product, identical with that obtained as in (a).

Aufarbeitung

  1. distillationat room temperature, the solvent is distilled in vacuo
  2. additionthe residue is added to 5% aqueous HCl
  3. extractionextracted with ether

Quellen und Nachweise

ORD-Eintrag
ord-f956151d754e4214abeff007d693b905
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04614833

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