Thionyl Chloride → HCID 59354817, Verbindung
Reaktionsgleichung
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][C:20]([OH:22])=O)=[CH:15][CH:14]=1.O=S(Cl)[Cl:25]>>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][C:20]([Cl:25])=[O:22])=[CH:15][CH:14]=1Komponenten
3
Versuchsvorschrift
A mixture of acid 2-(4-(quinolin-2-ylmethoxy)phenyl)acetic acid (2.0 g, 6.8 mmol) in SOCl2 (10 mL) was stirred at RT for 2 h under an inert atmosphere. The reaction was concentrated in vacuo to afford 2-(4-(quinolin-2-ylmethoxy)phenyl)acetyl chloride (2.0 g, 95%) as a light yellow solid.
Aufarbeitung
- concentrationThe reaction was concentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-fd417897652d4f0c990a4608ee0cbed9