Monomethylamine methanol → HCID 57499603, Verbindung
Reaktionsgleichung
CO.[CH3:3][NH2:4].C(O[C:8]([C:10]1[CH:14]=[C:13]([O:15][CH2:16][CH2:17][CH2:18][N:19]2[CH2:24][CH2:23][N:22]([C:25]3[C:33]4[CH:32]=[CH:31][S:30][C:29]=4[CH:28]=[CH:27][CH:26]=3)[CH2:21][CH2:20]2)[N:12]([CH2:34][CH:35]=[CH2:36])[N:11]=1)=[O:9])C>CO>[CH3:3][NH:4][C:8]([C:10]1[CH:14]=[C:13]([O:15][CH2:16][CH2:17][CH2:18][N:19]2[CH2:20][CH2:21][N:22]([C:25]3[C:33]4[CH:32]=[CH:31][S:30][C:29]=4[CH:28]=[CH:27][CH:26]=3)[CH2:23][CH2:24]2)[N:12]([CH2:34][CH:35]=[CH2:36])[N:11]=1)=[O:9]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
40% methylamine methanol solution (5 ml) was added to a methanol solution (5 ml) of 1-allyl-5-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-1H-pyrazole-3-carboxylic acid ethyl ester (0.5 g, 1.1 mmol) and the mixture was stirred at room temperature for 3 days. The solution was concentrated under reduced pressure and the residue was purified by basic silica gel column chromatography (n-hexane:ethyl acetate=5:1→0:1). The purified product was concentrated under reduced pressure and the residue was recrystallized from a solvent mixture of ethyl acetate-diisopropylether to obtain 1-allyl-5-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-1H-pyrazole-3-carboxylic acid methylamide (0.32 μg, 67% yield) as white powder.