Hydrochloric Acid → (4-Pyrazol-1-yl-phenyl)-hydrazine Hydrochloride

HRID 655866Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 655866
C(OC([N:8]([C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH:20]=[CH:19][CH:18]=[N:17]2)=[CH:12][CH:11]=1)[NH2:9])=O)(C)(C)C.O1CCOCC1.[ClH:27]>C(Cl)Cl>[ClH:27].[N:16]1([C:13]2[CH:14]=[CH:15][C:10]([NH:8][NH2:9])=[CH:11][CH:12]=2)[CH:20]=[CH:19][CH:18]=[N:17]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 68820898N-(4-Pyrazol-1-yl-phenyl)-hydrazinecarboxylic Acid tert-butyl Ester

Produkt 1

HCID 68824303(4-Pyrazol-1-yl-phenyl)-hydrazine Hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Title compound 51A, N-(4-Pyrazol-1-yl-phenyl)-hydrazinecarboxylic acid tert-butyl ester (0.42 g, 1.0 eq, 1.53 mmol) was suspended in a mixture of 4M HCl in Dioxane (6.5 ml, 17.0 eq, 26 mmol) and DCM (5 ml). The mixture was then stirred at room temperature for 24 hours solvent was then removed in vacuo to yield impure title compound. (0.31 g). LCMS: [M+H]+=158/175, 65% purity.

Aufarbeitung

  1. customwas then removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-2f4bf8455d0a404b990f424296af13c9
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08071607B2

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