Hydrochloric Acid → HCID 70166468, Verbindung

HRID 65594Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 65594
[CH3:1][O:2][C:3](=[O:30])[C@H:4]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[NH:5][C:6](=[O:21])[C@H:7]([CH2:19][OH:20])[NH:8]C(OCC1C=CC=CC=1)=O.[ClH:31].[H][H]>CO>[ClH:31].[CH3:1][O:2][C:3](=[O:30])[C@H:4]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[NH:5][C:6](=[O:21])[C@H:7]([CH2:19][OH:20])[NH2:8]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 13190522Z-Ser-Tyr-OMeHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 70166468HCID 70166468, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

To a mixture consisting of 4.16 g. of N-benzyloxycarbonyl-L-seryl-L-tyrosine methyl ester [for the preparation of this compound see J. Am. Chem. Soc., 76, 5076 (1954)], 30 ml. of methanol, and 416 mg. of 5% palladium-on-barium sulfate is added 8.7 ml. of methanol containing 400 mg. of hydrogen chloride, and hydrogen is passed over the stirred mixture for 75 minutes. The mixture is then filtered to remove the catalyst, and the filtrate is evaporated to dryness under reduced pressure to give a solid residue of L-seryl-L-tyrosine methyl ester hydrochloride, which is suitable for use without further purification.

Aufarbeitung

  1. filtrationThe mixture is then filtered
  2. customto remove the catalyst
  3. customthe filtrate is evaporated to dryness under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a43679a8b75349c3aad8097a4b646581
Quelldatensatz
uspto-grants-1978_12
Patentnummer
US04128540

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