Hydrazine → 3-amino-N-(2-chlorobenzyl)-2,2-dimethylpropanamide

HRID 655959Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 655959
[Cl:1][C:2]1[CH:26]=[CH:25][CH:24]=[CH:23][C:3]=1[CH2:4][NH:5][C:6](=[O:22])[C:7]([CH3:21])([CH3:20])[CH2:8][N:9]1C(=O)C2C(=CC=CC=2)C1=O.NN>CO>[NH2:9][CH2:8][C:7]([CH3:21])([CH3:20])[C:6]([NH:5][CH2:4][C:3]1[CH:23]=[CH:24][CH:25]=[CH:26][C:2]=1[Cl:1])=[O:22]

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 59778496N-(2-chlorobenzyl)-3-(1,3-dioxoisoindolin-2-yl)-2,2-dimethylpropanamide

Produkt 1

HCID 597784043-amino-N-(2-chlorobenzyl)-2,2-dimethylpropanamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of N-(2-chlorobenzyl)-3-(1,3-dioxoisoindolin-2-yl)-2,2-dimethylpropanamide (0.50 g, 1.35 mmol) in methanol (5 mL) was added hydrazine (423 μL, 13.5 mmol, 10 equiv.). The reaction mixture was stirred overnight. The crude mixture was concentrated. The resulting residue was dried in vacuum to give 3-amino-N-(2-chlorobenzyl)-2,2-dimethylpropanamide, which was used without further purification. LRMS (M+H+) m/z 241.1.

Aufarbeitung

  1. concentrationThe crude mixture was concentrated
  2. customThe resulting residue was dried in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-2e839ab4901d47c09e9a17f884e7b1dc
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08071625B2

Notizen zur Reaktion

Wird geladen…