Azetidine → 1-[(5-Bromo-2-thienyl)methyl]azetidine

HRID 656143Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 656143
[Br:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[CH2:12][CH2:11][CH2:10]C2)=[CH:4][CH:3]=1.N1CCC1>>[Br:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[CH2:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 10422AzetidineHCID 593327581-[(5-Bromo-2-thienyl)methyl]pyrrolidine

Produkt 1

HCID 593327501-[(5-Bromo-2-thienyl)methyl]azetidine

Versuchsvorschrift

The above procedure to make 1-[(5-bromo-2-thienyl)methyl]pyrrolidine was repeated except using azetidine (86 mg, 1.5 mmol) as the amine. Following the purification with the SCX column as described -[(5-bromo-2-thienyl)methyl]pyrrolidine an additional purification step on a 40 g ISCO silica column was necessary to afford the title compound (166 mg) of acceptable purity for use in the next reaction.

Aufarbeitung

  1. customthe purification with the SCX column
  2. customan additional purification step on a 40 g ISCO silica column

Quellen und Nachweise

ORD-Eintrag
ord-694a762037994be086c38cf13e634772
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08071584B2

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