Methylamine → HCID 66707598, Verbindung

HRID 656222Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 656222
[CH3:1][NH2:2].C[O:4][C:5](=O)[CH2:6][CH2:7][CH:8]1[CH2:13][CH2:12][CH:11]=[CH:10][CH2:9]1>CO>[CH:8]1([CH2:7][CH2:6][C:5]([NH:2][CH3:1])=[O:4])[CH2:13][CH2:12][CH:11]=[CH:10][CH2:9]1

Komponenten

4

Edukt 2

HCID 6329Methylamine2×HCID 12772855Methyl 3-(cyclohex-3-en-1-yl)propanoate

Produkt 1

HCID 66707598HCID 66707598, VerbindungAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl amine (8 M in EtOH, 75 ml, 600 mmol) was added to a mixture of 3-cyclohex-3-enyl-propionic acid methyl ester (German patent DE 4023848 A1 19920130) (20.0 g, 119 mmol) in 75 mL of methanol. The mixture was stirred at room temperature for one day. Additional Methyl amine (8 M in EtOH, 40 ml, 320 mmol) was added to the mixture and stirring continued for one more day. The mixture was concentrated and the residue was taken up in ethyl acetate, washed with 0.5 M aqueous HCl, dried and stripped of the solvent to give the title compound (19.50 g, 98% yield, uncorrected) as a pale orange solid.

Aufarbeitung

  1. stirringstirring
  2. concentrationThe mixture was concentrated
  3. washwashed with 0.5 M aqueous HCl
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-f8a95b11120a458fa867e3bbf86e5931
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08071643B2

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