(1-methyl-1H-pyrrol-2-yl)methanamine → 1-(4-t-butylbenzyl)-3-(1-methyl-1H-pyrrol-2-yl)methylthiourea

HRID 656288Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 656288
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][NH2:8].[C:9]([C:13]1[CH:22]=[CH:21][C:16]([CH2:17][N:18]=[C:19]=[S:20])=[CH:15][CH:14]=1)([CH3:12])([CH3:11])[CH3:10]>C(OCC)(=O)C>[C:9]([C:13]1[CH:22]=[CH:21][C:16]([CH2:17][NH:18][C:19]([NH:8][CH2:7][C:3]2[N:2]([CH3:1])[CH:6]=[CH:5][CH:4]=2)=[S:20])=[CH:15][CH:14]=1)([CH3:12])([CH3:10])[CH3:11]

Komponenten

4

Edukt 2

HCID 2776207(1-methyl-1H-pyrrol-2-yl)methanamineHCID 148010411-Tert-butyl-4-(isothiocyanatomethyl)benzene

Produkt 1

HCID 590880651-(4-t-butylbenzyl)-3-(1-methyl-1H-pyrrol-2-yl)methylthioureaAusbeute 75,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

(1-methyl-1H-pyrrol-2-yl)methylamine (65 mg) and 4-t-butylbenzylisothiocyanate (120 mg) were dissolved in ethyl acetate (30 ml) and the solution was stirred for 12 hours. After the completion of the reaction, the resulting mixture was purified by column-chromatography (ethyl acetate/hexane=1/3) to yield the compound 17-2 (140 mg, 75%)

Aufarbeitung

  1. customAfter the completion of the reaction
  2. customthe resulting mixture was purified by column-chromatography (ethyl acetate/hexane=1/3)

Quellen und Nachweise

ORD-Eintrag
ord-ad0f65674d824e39a75806ea578f636e
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08071650B2

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