Hydrochloric Acid → Ethyl ({4-amino-6-chloro-2-[(E)-2-phenylethenyl]-5-pyrimidinyl}oxy)acetate

HRID 657093Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 657093
Cl.[NH2:2][C:3]1[C:8]([O:9][CH2:10][C:11](N)=[O:12])=[C:7]([Cl:14])[N:6]=[C:5](/[CH:15]=[CH:16]/[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:4]=1.[CH2:23]([OH:25])[CH3:24]>>[NH2:2][C:3]1[C:8]([O:9][CH2:10][C:11]([O:25][CH2:23][CH3:24])=[O:12])=[C:7]([Cl:14])[N:6]=[C:5](/[CH:15]=[CH:16]/[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:4]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 866353532-({4-amino-6-chloro-2-[(E)-2-phenylethenyl]-5-pyrimidinyl}oxy)acetamide

Produkt 1

HCID 57928064Ethyl ({4-amino-6-chloro-2-[(E)-2-phenylethenyl]-5-pyrimidinyl}oxy)acetateAusbeute 84 %

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Hydrogen chloride gas was bubbled into a solution of 2-({4-amino-6-chloro-2-[(E)-2-phenylethenyl]-5-pyrimidinyl}oxy)acetamide (0.6 g, 1.97 mmol) in ethanol (20 mL). The resulting mixture was heated at 100° C. for 3 h. The mixture was evaporated under reduced pressure to give the desired product as a solid (0.55 g, 84%) which was used without purification.

Aufarbeitung

  1. customThe mixture was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-165af224578642759cd082e89465ff24
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08071592B2

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