HCID 68908311, Verbindung → HCID 178479702, Verbindung
Reaktionsgleichung
[O:1]=[C:2]1[CH2:7][CH2:6][CH:5]([C:8]2[CH:22]=[CH:21][C:11]([O:12][CH2:13][CH2:14][CH2:15][N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[ClH:23].OC1CCC(C2C=CC(OCCCN3CCC[C@H](C)C3)=CC=2)CC1>>[ClH:23].[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([C:8]2[CH:22]=[CH:21][C:11]([O:12][CH2:13][CH2:14][CH2:15][N:16]3[CH2:17][CH2:18][CH2:19][CH2:20]3)=[CH:10][CH:9]=2)[CH2:4][CH2:3]1Komponenten
3
Versuchsvorschrift
A Reduction of 1-{3-[4-(4-oxocyclohexyl)phenoxy]propyl}pyrrolidine (456 mg) as described for (3S)-1-{3-[4-(4-hydroxycyclohexyl)phenoxy]propyl}-3-methylpiperidine, hydrochloride affords 120 mg of 1-{3-[trans-4-(4-hydroxycyclo-hexyl)phenoxy]propyl}pyrrolidine, hydrochloride as a white solid melting at 225° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-e09eec7ac8544ac5b3c3f42c7c207926
- Quelldatensatz
- uspto-grants-2011_12