3,N-Dimethoxy-N-methyl-5-(pentafluorosulfanyl)benzamide → 1-[3-Methoxy-5-(pentafluorosulfanyl)phenyl]ethanone

HRID 657952Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 657952
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:12]=[C:13]([S:15]([F:20])([F:19])([F:18])([F:17])[F:16])[CH:14]=1)[C:6](N(OC)C)=[O:7].[CH3:21][Mg]Br>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:6](=[O:7])[CH3:21])[CH:12]=[C:13]([S:15]([F:17])([F:20])([F:19])([F:16])[F:18])[CH:14]=1

Komponenten

4

Edukt 2

HCID 581369683,N-Dimethoxy-N-methyl-5-(pentafluorosulfanyl)benzamideHCID 178418573HCID 178418573, Verbindung

Produkt 1

HCID 441831181-[3-Methoxy-5-(pentafluorosulfanyl)phenyl]ethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

3,N-Dimethoxy-N-methyl-5-(pentafluorosulfanyl)benzamide (O3.007; 2.0 g) was dissolved in absolute THF (60 ml), and methylmagnesium bromide (5.2 ml, 3 M in diethyl ether) was added dropwise at 0° C. while stirring. After addition, the ice bath was removed and the mixture was stirred at RT for 2 h. 1 N hydrochloric acid was then added dropwise while cooling, followed by water and ethyl acetate. The organic phase was removed and the aqueous phase was extracted twice more with ethyl acetate. The combined extracts were dried over magnesium sulfate, filtered and concentrated. The residue was purified by means of preparative HPLC (met. A). The product-containing fractions were combined, freed of the acetonitrile and extracted three times with ethyl acetate. The combined extracts were dried over magnesium sulfate, filtered and concentrated. 1.63 g of the desired compound were obtained.

Aufarbeitung

  1. additionAfter addition
  2. customthe ice bath was removed
  3. stirringthe mixture was stirred at RT for 2 h
  4. addition1 N hydrochloric acid was then added dropwise
  5. temperaturewhile cooling
  6. customThe organic phase was removed
  7. extractionthe aqueous phase was extracted twice more with ethyl acetate
  8. dry with materialThe combined extracts were dried over magnesium sulfate
  9. filtrationfiltered
  10. concentrationconcentrated
  11. customThe residue was purified by means of preparative HPLC (
  12. extractionextracted three times with ethyl acetate
  13. dry with materialThe combined extracts were dried over magnesium sulfate
  14. filtrationfiltered
  15. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-e3e65d12d846496aaa5a6c3469e658b2
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08076336B2

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