1,2,4-Trifluoro-5-nitrobenzene → 4-Amino-2,5-difluorophenol
Reaktionsgleichung
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[C:5]([F:11])=[CH:4][C:3]=1F.NC1C(F)=CC([OH:21])=CC=1F>>[NH2:8][C:6]1[C:5]([F:11])=[CH:4][C:3]([OH:21])=[C:2]([F:1])[CH:7]=1Komponenten
3
Versuchsvorschrift
This compound was prepared from 1,2,4-trifluoro-5-nitrobenzene (5.0 g, 28 mmol) in the manner described for 4-amino-3,5-difluorophenol, affording 3.0 g (72.3%) of 4-amino-2,5-difluorophenol. 1H-NMR (DMSO-d6) δ 9.04 (s, 1H), 6.67 to 6.46 (m, 2H), 4.64 (s, 2H); MS GC-MS M+=146.1, RT=1.04 min.
Quellen und Nachweise
- ORD-Eintrag
- ord-beffefa8108c45c689635d96172d0fc0
- Quelldatensatz
- uspto-grants-2011_12
- Patentnummer
- US08076488B2
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