[(R)-2-(2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester → [(R)-3-(2-tert-Butylcarbamoyl-5-methoxy-phenyl)-1-(2-fluoro-benzyl)-2-oxo-propyl]-carbamic acid tert-butyl ester

HRID 658545Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 658545
[C:1]([O:5][C:6](=[O:23])[NH:7][C@@H:8]([C:17](=[O:22])N(OC)C)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[F:16])([CH3:4])([CH3:3])[CH3:2].[C:24]([NH:28][C:29](=[O:39])[C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][C:31]=1[CH3:38])([CH3:27])([CH3:26])[CH3:25]>>[C:1]([O:5][C:6](=[O:23])[NH:7][C@H:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[F:16])[C:17](=[O:22])[CH2:38][C:31]1[CH:32]=[C:33]([O:36][CH3:37])[CH:34]=[CH:35][C:30]=1[C:29](=[O:39])[NH:28][C:24]([CH3:26])([CH3:25])[CH3:27])([CH3:2])([CH3:3])[CH3:4]

Komponenten

3

Edukt 2

HCID 59799859[(R)-2-(2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl esterHCID 59804557N-tert-Butyl-4-methoxy-2-methyl-benzamide

Produkt 1

HCID 69109240[(R)-3-(2-tert-Butylcarbamoyl-5-methoxy-phenyl)-1-(2-fluoro-benzyl)-2-oxo-propyl]-carbamic acid tert-butyl ester

Versuchsvorschrift

Using general procedure 2 with [(R)-2-(2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester (1.4 g, 4.29 mmol) and N-tert-Butyl-4-methoxy-2-methyl-benzamide (2.8 g, 13 mmol) followed by purification by silica gel flash column chromatography gives the title compound.

Aufarbeitung

  1. customfollowed by purification by silica gel flash column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-8e9e98aced7d4ac2ac9a25854c424705
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08076514B2

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