3,5-Bis(tert-butyldimethylsilyloxy)benzaldehyde → Ethyl 2-(3,5-bis(tert-butyldimethylsilyloxy)benzylamino)-2-methylpropanoate

HRID 658762Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 658762
[Si:1]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[C:15]([O:17][Si:18]([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:20])[CH3:19])[CH:16]=1)[CH:12]=O)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].Cl.[NH2:26][C:27]([CH3:34])([CH3:33])[C:28]([O:30][CH2:31][CH3:32])=[O:29]>>[Si:1]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[C:15]([O:17][Si:18]([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:19])[CH3:20])[CH:16]=1)[CH2:12][NH:26][C:27]([CH3:34])([CH3:33])[C:28]([O:30][CH2:31][CH3:32])=[O:29])([C:4]([CH3:6])([CH3:5])[CH3:7])([CH3:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 109155453,5-Bis(tert-butyldimethylsilyloxy)benzaldehydeHCID 22343822Ethyl 2-amino-2-methylpropanoate hydrochloride

Produkt 1

HCID 59524418Ethyl 2-(3,5-bis(tert-butyldimethylsilyloxy)benzylamino)-2-methylpropanoateAusbeute 88 %

Versuchsvorschrift

Prepared as in Example 12-1b from 3,5-bis(tert-butyldimethylsilyloxy)benzaldehyde (Example 12-3c) and ethyl 2-amino-2-methylpropanoate hydrochloride. Yield 88%, colorless liquid. MS 482 (MH+).

Quellen und Nachweise

ORD-Eintrag
ord-f0b19d95d6184681a660ec41e60bba83
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08076491B2

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