HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diisopropylethylamine → 3-{3-[(5-Benzoyl-furan-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | 3-Aminocinnamic acid ethyl ester | HCID 97825 | — |
| Edukt | 5-Benzoylfuran-2-carboxylic acid | HCID 2877255 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 3-{3-[(5-Benzoyl-furan-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester | HCID 68412610 | — |
Reaktionsschritte
Acid (9) (48 mg, 0.22 mmol) was coupled to aniline (2) (43 mg, 0.22 mmol) using Method B, except that DIPEA (57 mg, 0.44 mmol) and DMF (0.5 mL) were used. The crude product was purified by preparative HPLC to give the title compound. Yield: 28 mg; LC-MS tr 41.54 min; MS (ES+) m/z 389 (M+H)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08080567B2 |
| Quelldatensatz | uspto-grants-2011_12 |
| ORD ID | ord-1a215cd9103e447a89e05584481b6c9e |
| Quellennotiz | uspto-grants-2011_12 |