HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Aminocinnamic acid ethyl ester → 3-{3-[(Dibenzofuran-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Aminocinnamic acid ethyl ester | HCID 97825 | — |
| Edukt | 8-Oxatricyclo(7.4.0.0,2,7)trideca-1(9),2(7),3,5,10,12-hexaene-4-carboxylic acid | HCID 417404 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 3-{3-[(Dibenzofuran-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester | HCID 68413672 | — |
Reaktionsschritte
Acid (18) (50 mg, 0.24 mmol) was coupled to aniline (2) (54 mg, 0.28 mmol) using Method D, except that DMF (1 mL) was used. The product was further purified by trituration in DCM/heptane to give the title compound. Yield: 46 mg, 51%; LC-MS tr 1.70 min; HPLC Purity: 97-100%; MS (ES+) m/z 386 (M+H)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08080567B2 |
| Quelldatensatz | uspto-grants-2011_12 |
| ORD ID | ord-b2c3063bdbde41079b807c139c24d1af |
| Quellennotiz | uspto-grants-2011_12 |