1,3-Dimethyl-6-hydroxylaminouracil → Isoxazolo(3,4-d)pyrimidine-4,6(5H,7H)-dione, 5,7-dimethyl-

HRID 65915Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 65915
[CH3:1][N:2]1[C:9]([NH:10][OH:11])=[CH:8][C:6](=[O:7])[N:5]([CH3:12])[C:3]1=[O:4].[CH:13]([O-])([O-])OCC>CN(C)C=O>[CH3:12][N:5]1[C:6](=[O:7])[C:8]2=[CH:13][O:11][N:10]=[C:9]2[N:2]([CH3:1])[C:3]1=[O:4]

Komponenten

4

Edukt 2

HCID 27859331,3-Dimethyl-6-hydroxylaminouracilHCID 53630039Ethylorthoformate

Produkt 1

HCID 2785556Isoxazolo(3,4-d)pyrimidine-4,6(5H,7H)-dione, 5,7-dimethyl-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 2 g of 1,3-dimethyl-6-hydroxyaminouracil, 20 ml of dimethylformamide and 20 ml of ethyl orthoformate is boiled at 160° C. for 1 hour, after which the solvent is distilled off. To the residue is added ethanol and the resultant crystals are collected by filtration. As recrystallized from hot water, 1.0 g of the captioned compound is obtained as colorless prisms, melting point: 170°-171° C.

Aufarbeitung

  1. customfor 1 hour
  2. distillationafter which the solvent is distilled off
  3. additionTo the residue is added ethanol
  4. filtrationthe resultant crystals are collected by filtration
  5. customAs recrystallized from hot water

Quellen und Nachweise

ORD-Eintrag
ord-236fd08383f64e2cb363e09d99783ced
Quelldatensatz
uspto-grants-1978_12
Patentnummer
US04129654

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