Cyclopentanone → N-((1RS,2SR)-2-Cyclopentylamino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide

HRID 659239

Reaktionsgleichung

Reaktionsgleichung von HRID 659239
[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9](=[O:26])[C:10]1[C:15]([C:16]([F:19])([F:18])[F:17])=[CH:14][C:13]([C:20]([F:23])([F:22])[F:21])=[CH:12][C:11]=1[O:24][CH3:25].[C:27]1(=O)[CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH:27]1([NH:1][CH:2]2[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]2[NH:8][C:9](=[O:26])[C:10]2[C:15]([C:16]([F:19])([F:18])[F:17])=[CH:14][C:13]([C:20]([F:21])([F:22])[F:23])=[CH:12][C:11]=2[O:24][CH3:25])[CH2:31][CH2:30][CH2:29][CH2:28]1

Komponenten

3

Edukt 2

HCID 8452CyclopentanoneHCID 58062915cis-N-(2-Amino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide2×

Produkt 1

HCID 51001074N-((1RS,2SR)-2-Cyclopentylamino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide

Versuchsvorschrift

The title compound, off-white foam, MS: m/e=453.2 [(M+H)+], was prepared in accordance with the general method of example 11 from cis-N-(2-amino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide (intermediate H) and cyclopentanone.

Quellen und Nachweise

ORD-Eintrag
ord-b5b676e1d63643beb6e0d5e99b729835
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08080541B2

Verknüpfte Notizen

Wird geladen…