Hydrochloric Acid → 3-(1H-imidazol-2-yl)piperidine hydrochloride

HRID 659621Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 659621
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]1[CH2:11][CH2:10][CH2:9][N:8](C(OCC2C=CC=CC=2)=O)[CH2:7]1.Cl.C(Cl)[Cl:24].CO>O1CCOCC1>[ClH:24].[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]1[CH2:11][CH2:10][CH2:9][NH:8][CH2:7]1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6344DichloromethaneHCID 67996237benzyl 3-(1H-imidazol-2-yl)piperidine-1-carboxylate

Produkt 1

HCID 679965363-(1H-imidazol-2-yl)piperidine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

A 250-mL round-bottomed flask was charged with a solution of benzyl 3-(1H-imidazol-2-yl)piperidine-1-carboxylate (1.5 g, 5.26 mmol, 1.00 equiv) in dioxane (15 mL). To this was added conc. HCl (9 mL). The resulting mixture was stirred for 4 hours at 70° C. in an oil bath. The reaction progress was monitored by TLC (DCM: MeOH=10:1). Upon completion, the resulting solution was diluted with dioxane (10 mL) and concentrated on a rotary evaporator affording 3-(1H-imidazol-2-yl)piperidine hydrochloride as black solid in (0.48 g, 57%).

Aufarbeitung

  1. concentrationconcentrated on a rotary evaporator

Quellen und Nachweise

ORD-Eintrag
ord-a959826435da479dabb1297263d49589
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08080566B1

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