Ethyl trifluoroacetate → 1-Trifluoroacetyl-4-hydroxy-4-phenylpiperidine

HRID 65969Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 65969
[OH:1][C:2]1([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[F:14][C:15]([F:22])([F:21])[C:16](OCC)=[O:17]>>[F:14][C:15]([F:22])([F:21])[C:16]([N:5]1[CH2:6][CH2:7][C:2]([OH:1])([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:3][CH2:4]1)=[O:17]

Komponenten

3

Edukt 2

HCID 9794Ethyl trifluoroacetateHCID 963874-Phenylpiperidin-4-ol

Produkt 1

HCID 14465131-Trifluoroacetyl-4-hydroxy-4-phenylpiperidine

Versuchsvorschrift

The starting material is prepared as follows: The mixture of 25 g of 4-hydroxy-4-phenylpiperidine and 50 ml of ethyl trifluoroacetate is refluxed overnight and evaporated. The residue is taken up in benzene, the solution washed with 1N hydrochloric acid, dried and evaporated. The residue is recrystallized from ethyl acetate-petroleum ether, to yield the 1-trifluoroacetyl-4-hydroxy-4-phenylpiperidine melting at 123°-125°.

Aufarbeitung

  1. customThe starting material is prepared
  2. temperatureis refluxed overnight
  3. customevaporated
  4. washthe solution washed with 1N hydrochloric acid
  5. customdried
  6. customevaporated
  7. customThe residue is recrystallized from ethyl acetate-petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-85b342c49efc47bd97c2025dfa1e28f5
Quelldatensatz
uspto-grants-1978_12
Patentnummer
US04129655

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