4-[2-(5-Amino-2-methyl-phenylamino)-oxazol-5-yl]-benzonitrile → 4-(2-(5-Amino-2-methylphenylamino)-4-chlorooxazol-5-yl)-2,6-dimethylbenzonitrile
Reaktionsgleichung
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:22])=[C:6]([NH:8]C2OC(C3C=CC(C#N)=CC=3)=CN=2)[CH:7]=1.Cl[C:24]1[O:25][C:26]([C:30]2[CH:37]=[C:36]([CH3:38])[C:33]([C:34]#[N:35])=[C:32]([CH3:39])[CH:31]=2)=[C:27]([Cl:29])[N:28]=1.ClC1OC(C2C=CC(C#N)=CC=2)=CN=1>>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:22])=[C:6]([NH:8][C:24]2[O:25][C:26]([C:30]3[CH:37]=[C:36]([CH3:38])[C:33]([C:34]#[N:35])=[C:32]([CH3:39])[CH:31]=3)=[C:27]([Cl:29])[N:28]=2)[CH:7]=1Komponenten
4
Edukt 3
Produkt 1
Versuchsvorschrift
The same procedure outlined above in the preparation of 4-[2-(5-Amino-2-methyl-phenylamino)-oxazol-5-yl]-benzonitrile was used. However 4-(2,4-dichlorooxazol-5-yl)-2,6-dimethylbenzonitrile was used instead 4-(2-Chloro-oxazol-5-yl)-benzonitrile. Yield=74%.